Microinvasive breast cancer

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Background: Ductal carcinoma in situ DCIS is a neoplastic proliferation of epithelial cells which is confined within the basement membrane of the mammary ductal-lobular system. It is of interest to determine to what extent the potential to metastasize increases for DCIS patients when the basement membrane is breached i. For each patient, we extracted information on year of diagnosis, age at diagnosis, tumour size, tumour grade, oestrogen receptor status, use of radiotherapy, type of surgery, cause of death and follow-up time. We classified patients into four groups, according to the size of the invasive component of the primary tumour.

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Breast Cancer Patients with Very Small Tumors May Skip Lymph Node Biopsies, Study Suggests

Microinvasive Breast Cancer Faculty Article | Rutgers Cancer Institute of New Jersey

Breast cancer usually begins either in the cells of the lobules, which are milk-producing glands, or the ducts, the passages that drain milk from the lobules to the nipple. The pathology report will tell you whether or not the cancer has spread outside the milk ducts or lobules of the breast where it started. Non-invasive cancers stay within the milk ducts or lobules in the breast. They do not grow into or invade normal tissues within or beyond the breast. Invasive cancers do grow into normal, healthy tissues. Most breast cancers are invasive. Whether the cancer is non-invasive or invasive will determine your treatment choices and how you might respond to the treatments you receive.

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microinvasion

Background: Microinvasive breast cancer T1mi is considered as a precursor of invasive cancer developing from ductal carcinoma in situ DCIS. This study discussed the clinicopathological and immunohistochemical features of T1mi by comparing those of ductal carcinoma in situ Tis and T1a to assess the nature and causes of the progression of Tis into invasive cancer. Methods: Three hundred and ninety-two Tis, 32 T1mi, and T1a lesions which were pathologically diagnosed in surgical specimens between and were analyzed retrospectively.

Background: Microinvasive breast cancer is an uncommon pathological entity. Owing to the rarity of this condition, its surgical axillary management and overall prognosis remain controversial. Methods: A database was analysed to identify patients with microinvasive ductal carcinoma in situ DCIS who had surgery for invasive breast cancer at the European Institute of Oncology, Milan, between and Women who had undergone axillary staging by sentinel lymph node biopsy were included in the study.

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